Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells
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چکیده
منابع مشابه
Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway
We investigated the underlying mechanism for the potent proapoptotic effect of paeoniflorin (PF) on human glioma cells in vitro, focusing on signal transducer and activator of transcription 3 (STAT3) signaling. Significant time- and dose-dependent apoptosis and inhibition of proliferation were observed in PF-treated U87 and U251 glioma cells. Expression of STAT3, its active form phosphorylated ...
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The ubiquitination and proteasome degradation pathway is a multistep enzymatic cascade in eukaryotes in which ubiquitin is conjugated via a lysine residue at position 48 to target proteins for destruction. Proteins tagged with lysine 48–linked chains of ubiquitin are marked for degradation in the proteasome enzyme complex (Figure 1). Through this pathway, the cell rids itself of excess and misf...
متن کاملKeratin Filaments of Cultured Human Epidermal Cells
Human epidermal cells grown in culture synthesize abundant keratins. These keratins are similar to those of stratum corneum of human epidermal callus in their insolubility in dilute aqueous buffers, their molecular weight range of 40,000 to 60,000, their immunological reactivity, and their ability to assemble into 80 A tonofilaments in u&-o; but there are differences in the molecular weights of...
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The p53-related p63 gene encodes multiple protein isoforms, which are involved in a variety of biological activities. p63 protein stability is mainly regulated by the ubiquitin-dependent proteasomal degradation pathway. Several ubiquitin E3 ligases have been identified and some protein kinases as well as other kinds of proteins are involved in regulation of p63 protein stability. These regulato...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2011
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2011.826